DMT-2'-O-MOE-T-CE Phosphoramidite / 5-Me-DMT-2'-O-MOE-U-CE Phosphoramidite Application_Diagnostics "The MOE modification of RNA:

"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field

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a benzoyl (Bz) base-protecting group on adenine

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DMT-2'-O-MOE-T-CE Phosphoramidite / 5-Me-DMT-2'-O-MOE-U-CE Phosphoramidite Application_Diagnostics "The MOE modification of RNA:DMT 2' O MOE T CE Phosphoramidite is a 2' MOE phosphoramidite monomer used for solid phase oligonucleotide synthesis. It contains a 5' dimethoxytrityl (DMT) protecting group for 5' hydroxyl protection, a thymine, a cyanoethyl (CE) protecting group on phosphite, and a 2' O methoxyethyl (MOE) modification. 2' O MOE provide enhanced nuclease resistance, duplex stability, and low cytotoxicity compared with unmodified RNA. Structurally, the 2' hydroxyl