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Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C27H50N8O10 Molecular Weight 646
Inhibitors
Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates
Product Name BC-PhN3 Synonyms CLIP-PhN3 CAS Number Related CAS Molecular Formula C19H17N7O2 Molecular Weight 375
Product Name 1-bromo-4-(methoxy-d3)benzene Synonyms 1-bromo-4-(²H3)methoxybenzene CAS Number 100835-59-4 Related CAS Molecular Formula C7H7BrO Molecular Weight 190
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG4) deuterium-labeled-halide Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX
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